Suppression of the cr-1 mutation in Neurospora crassa

Jpn J Genet. 1991 Feb;66(1):77-83. doi: 10.1266/jjg.66.77.


We have cloned a DNA fragment, which hybridized with the adenylate cyclase gene (CYR1) of Saccharomyces cerevisiae, from genomic DNA libraries of Neurospora crassa. The cr-1 mutation was able to be suppressed by introducing this DNA fragment on a cosmid vector, judging from recovery of the adenylate cyclase activity and the abnormal morphology.

MeSH terms

  • Adenylyl Cyclases / genetics*
  • Cloning, Molecular
  • Cosmids
  • DNA
  • Gene Library
  • Genetic Vectors
  • Hybridization, Genetic
  • Mutation*
  • Neurospora crassa / genetics*
  • Restriction Mapping
  • Saccharomyces cerevisiae / enzymology
  • Saccharomyces cerevisiae / genetics
  • Suppression, Genetic*


  • DNA
  • Adenylyl Cyclases