Functional coactivation map of the human brain

Cereb Cortex. 2008 Nov;18(11):2553-9. doi: 10.1093/cercor/bhn014. Epub 2008 Feb 21.


Understanding the interactions among different brain regions is fundamental to our understanding of brain function. Here we describe a complete map of functional connections in the human brain derived by an automatic meta-analysis of 825 neuroimaging articles, representing 3402 experiments. The likelihood of a functional connection between regions was estimated by studying the interdependence of their "activity," as reported in each experiment, across all experiments. We obtained a dense coactivation map that recovers some fundamental principles of the brain's functional connectivity, such as the symmetric interhemispheric connections, and important functional networks, such as the fronto-parietal attention network, the resting state network and the motor network.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural

MeSH terms

  • Brain / physiology*
  • Brain Mapping*
  • Databases, Factual*
  • Humans
  • Models, Neurological*