Tumor necrosis factor-alpha-converting enzyme (TACE) levels in periodontal diseases

J Dent Res. 2008 Mar;87(3):273-7. doi: 10.1177/154405910808700311.


Tumor necrosis factor-alpha-converting enzyme (TACE) is a metalloprotease which can shed several cytokines from the cell membrane, including receptor activator of NF-kappaB ligand (RANKL). This study aimed to investigate the hypothesis that TACE would be elevated in the gingival crevicular fluid (GCF) of persons with periodontitis. Total TACE amounts in GCF were higher in persons with chronic and aggressive periodontitis than in those with gingivitis or in healthy persons. TACE concentrations in GCF were higher in persons with chronic and aggressive periodontitis than in those with gingivitis, although not significantly higher than in healthy persons. Persons with chronic periodontitis receiving immunosuppressive treatment exhibited over 10-fold lower TACE levels than the other periodontitis groups. TACE was positively correlated with probing pocket depth, clinical attachment levels, and RANKL concentrations in GCF. In conclusion, the increased GCF TACE levels in persons with periodontitis and their positive correlation with RANKL may indicate an association of this enzyme with alveolar bone loss, and may warrant special attention in future therapeutic approaches.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ADAM Proteins / analysis*
  • ADAM Proteins / antagonists & inhibitors
  • ADAM17 Protein
  • Adolescent
  • Adult
  • Alveolar Bone Loss / enzymology
  • Alveolar Bone Loss / metabolism
  • Amyloid Precursor Protein Secretases / analysis*
  • Amyloid Precursor Protein Secretases / antagonists & inhibitors
  • Chronic Disease
  • Enzyme Inhibitors / pharmacology
  • Female
  • Gingival Crevicular Fluid / chemistry
  • Gingival Crevicular Fluid / enzymology
  • Gingival Hemorrhage / enzymology
  • Gingival Hemorrhage / metabolism
  • Gingivitis / enzymology
  • Gingivitis / metabolism
  • Humans
  • Immunosuppressive Agents / pharmacology
  • Immunosuppressive Agents / therapeutic use
  • Kidney Transplantation
  • Male
  • Middle Aged
  • Periodontal Attachment Loss / enzymology
  • Periodontal Pocket / enzymology
  • Periodontitis / enzymology*
  • Periodontitis / metabolism
  • Periodontium / enzymology
  • Periodontium / metabolism
  • RANK Ligand / analysis
  • Tumor Necrosis Factor-alpha / analysis*
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors


  • Enzyme Inhibitors
  • Immunosuppressive Agents
  • RANK Ligand
  • Tumor Necrosis Factor-alpha
  • Amyloid Precursor Protein Secretases
  • ADAM Proteins
  • ADAM17 Protein
  • ADAM17 protein, human