Risperidone and the treatment of psychiatric, motor, and cognitive symptoms in Huntington's disease

Ann Clin Psychiatry. 2008 Jan-Mar;20(1):1-3. doi: 10.1080/10401230701844802.


Background: Huntington's disease (HD) is a progressive, neuropsychiatric disorder, and limited reports indicate that risperidone might improve motor and psychiatric functioning for these patients.

Methods: In a retrospective, chart review study to evaluate the effectiveness of risperidone on motor, psychiatric, and cognitive functioning in HD, 17 patients taking risperidone in the course of clinical care and 12 patients not taking any antipsychotic medication were compared across a year.

Results: Patients taking risperidone demonstrated significantly improved psychiatric functioning and motor stabilization, whereas patients not taking risperidone were stable psychiatrically and worsened motorically.

Conclusions: Although controlled clinical trials are clearly needed, these preliminary results support the use of risperidone in patients with HD in treating their psychiatric and possibly motor symptoms.

MeSH terms

  • Activities of Daily Living / classification
  • Adult
  • Antipsychotic Agents / adverse effects
  • Antipsychotic Agents / therapeutic use*
  • Cognition Disorders / diagnosis
  • Cognition Disorders / drug therapy*
  • Female
  • Humans
  • Huntington Disease / diagnosis
  • Huntington Disease / drug therapy*
  • Male
  • Mental Disorders / diagnosis
  • Mental Disorders / drug therapy*
  • Middle Aged
  • Motor Activity / drug effects*
  • Neuropsychological Tests
  • Retrospective Studies
  • Risperidone / adverse effects
  • Risperidone / therapeutic use*


  • Antipsychotic Agents
  • Risperidone