Abstract
Cell viability during chronological aging and after apoptotic stimuli in some yeast mutants with altered mitochondrial morphology was followed; a function for the corresponding genes in the apoptotic process was assessed. MDM30 and DNM1, the genes encoding an F-box protein and the dynamin-related GTPase, respectively, are involved in triggering aging and apoptosis. In contrast, YME1, encoding a subunit of the mitochondrial inner membrane i-AAA proteinase complex, has a protective role in these processes. FIS1, the mitochondrial fission gene, might play a protective role after an apoptotic insult while it seems to promote cell death in aging cells.
MeSH terms
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ATP-Dependent Proteases
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Adenosine Triphosphatases / genetics
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Adenosine Triphosphatases / physiology
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Apoptosis
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F Factor / genetics
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F Factor / physiology
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F-Box Proteins / genetics
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F-Box Proteins / physiology
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GTP Phosphohydrolases / genetics
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GTP Phosphohydrolases / physiology
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Mitochondria / genetics
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Mitochondria / physiology*
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Mitochondrial Proteins / genetics
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Mitochondrial Proteins / physiology
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Mutation*
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Oxidative Stress
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Saccharomyces cerevisiae / cytology*
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / growth & development
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Saccharomyces cerevisiae / physiology*
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Saccharomyces cerevisiae Proteins / genetics
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Saccharomyces cerevisiae Proteins / physiology
Substances
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F-Box Proteins
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FIS1 protein, S cerevisiae
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Mdm30 protein, S cerevisiae
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Mitochondrial Proteins
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Saccharomyces cerevisiae Proteins
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ATP-Dependent Proteases
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YME1 protein, S cerevisiae
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Adenosine Triphosphatases
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GTP Phosphohydrolases
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DNM1 protein, S cerevisiae