Reactive oxygen species and yeast apoptosis

Biochim Biophys Acta. 2008 Jul;1783(7):1354-68. doi: 10.1016/j.bbamcr.2008.01.023. Epub 2008 Feb 11.


Apoptosis is associated in many cases with the generation of reactive oxygen species (ROS) in cells across a wide range of organisms including lower eukaryotes such as the yeast Saccharomyces cerevisiae. Currently there are many unresolved questions concerning the relationship between apoptosis and the generation of ROS. These include which ROS are involved in apoptosis, what mechanisms and targets are important and whether apoptosis is triggered by ROS damage or ROS are generated as a consequence or part of the cellular disruption that occurs during cell death. Here we review the nature of the ROS involved, the damage they cause to cells, summarise the responses of S. cerevisiae to ROS and discuss those aspects in which ROS affect cell integrity that may be relevant to the apoptotic process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins / metabolism
  • Antioxidants / metabolism
  • Apoptosis / genetics
  • Apoptosis / physiology*
  • Apoptosis Regulatory Proteins / metabolism
  • Cytoskeleton / metabolism
  • DNA Damage / physiology
  • Endoplasmic Reticulum / metabolism
  • Metals / metabolism
  • Mitochondria / metabolism*
  • Reactive Oxygen Species / metabolism*
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / physiology*
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Transcription Factors / metabolism*


  • Actins
  • Antioxidants
  • Apoptosis Regulatory Proteins
  • Metals
  • Reactive Oxygen Species
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • YAP1 protein, S cerevisiae