Differential sensitivity of calbindin and parvalbumin immunoreactive cells in the striatum to excitotoxins

Brain Res. 1991 Apr 19;546(2):329-35. doi: 10.1016/0006-8993(91)91497-o.


The neurotoxic effects of ibotenic acid, quinolinic acid and kainic acid on cells in the rat striatum were investigated using immunocytochemistry with antibodies to the calcium binding proteins, calbindin and parvalbumin. The results showed that both ibotenic acid and quinolinic acid affected calbindin and parvalbumin cells to the same extent. However, parvalbumin immunopositive neurons were more sensitive than calbindin immunopositive neurons to the neurotoxic effects of kainic acid. Although the reason for this increased sensitivity of parvalbumin striatal neurons to kainic acid is unclear, these results suggest that the neurotoxicity produced by kainic acid is different to that occurring with quinolinic acid and ibotenic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calbindins
  • Corpus Striatum / anatomy & histology
  • Corpus Striatum / cytology*
  • Corpus Striatum / drug effects
  • Ibotenic Acid / administration & dosage
  • Ibotenic Acid / pharmacology
  • Immunohistochemistry
  • Injections
  • Kainic Acid / administration & dosage
  • Kainic Acid / pharmacology
  • Parvalbumins / immunology
  • Parvalbumins / physiology*
  • Quinolinic Acid
  • Quinolinic Acids / administration & dosage
  • Quinolinic Acids / pharmacology
  • Rats
  • S100 Calcium Binding Protein G / immunology
  • S100 Calcium Binding Protein G / physiology*


  • Calbindins
  • Parvalbumins
  • Quinolinic Acids
  • S100 Calcium Binding Protein G
  • Ibotenic Acid
  • Quinolinic Acid
  • Kainic Acid