Caveolin-1: a tumor-promoting role in human cancer

Int J Radiat Biol. 2008 Mar;84(3):177-89. doi: 10.1080/09553000701745293.


Purpose: Caveolae are non-clathrin, flask-shaped invaginations of the plasma membrane. Caveolin-1 is an essential constituent of caveolae and as such acts as a regulator of caveolae-dependent lipid trafficking and endocytosis. Caveolin-1 interacts with a variety of cellular proteins and regulates cell-signaling events. Caveolin-1 appears to act as a tumor suppressor protein at early stages of cancer progression. However, a growing body of evidence indicates that caveolin-1 is up-regulated in several multidrug-resistant and metastatic cancer cell lines and human tumor specimens. Furthermore, caveolin-1 levels are positively correlated with tumor stage and grade in numerous cancer types.

Conclusion: The available experimental data support the tumor-promoting role of caveolin-1 in advanced-stage cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Caveolae / physiology*
  • Caveolin 1 / biosynthesis
  • Caveolin 1 / physiology*
  • Cell Proliferation
  • Cell Survival / physiology
  • Cell Transformation, Neoplastic / metabolism*
  • Cell Transformation, Neoplastic / pathology
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Humans
  • Neoplasm Metastasis
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Signal Transduction*
  • Tumor Suppressor Proteins / biosynthesis
  • Tumor Suppressor Proteins / physiology


  • Caveolin 1
  • Tumor Suppressor Proteins