Serum cystatin C as an endogenous marker of renal function in patients with chronic kidney disease

Ren Fail. 2008;30(2):181-6. doi: 10.1080/08860220701810315.


The estimation of the glomerular filtration rate (GFR) is an essential part of the evaluation of patients with chronic kidney disease (CKD). Recently, serum cystatin C has been proposed as a new endogenous marker of GFR. Authors compared serum creatinine, creatinine clearance calculated from Cockcroft and Gault formula and serum cystatin C against (51)CrEDTA clearance in 252 patients with CKD and GFR <90 mL/min/1.73 m(2). Analysis of correlations and diagnostic accuracy (receiver operating characteristic curves) of different GFR markers indicate that serum cystatin C is a more reliable marker of GFR in patients with CKD than serum creatinine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • Cohort Studies
  • Creatinine / blood*
  • Cystatin C
  • Cystatins / blood*
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Glomerular Filtration Rate / physiology*
  • Humans
  • Kidney Failure, Chronic / blood
  • Kidney Failure, Chronic / diagnosis*
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Probability
  • ROC Curve
  • Risk Assessment
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Sex Factors


  • Biomarkers
  • CST3 protein, human
  • Cystatin C
  • Cystatins
  • Creatinine