Three-dimensional time-of-flight (3D TOF) magnetic resonance angiography (MRA) and contrast-enhanced MRA of intracranial aneurysms treated with platinum coils

Acta Radiol. 2008 Mar;49(2):190-6. doi: 10.1080/02841850701732940.


Background: Contrast-enhanced magnetic resonance angiography (CE-MRA) is less prone to flow-related signal intensity loss than three-dimensional time-of-flight (3D TOF) MRA and may therefore be more sensitive for detection of residual patency in platinum coil-treated intracranial aneurysms.

Purpose: To compare MRA and CE-MRA in the follow-up of intracranial aneurysms treated with platinum coils.

Material and methods: CE-MRA and 3D TOF MRA (pre- and postcontrast injection) of the intracranial vasculature was performed at 1.5T in 38 patients (47 aneurysms) referred for DSA in the follow-up of coiled intracranial aneurysms.

Results: DSA showed aneurysm patency in 22/47 investigations. Patent aneurysm components were observed with CE-MRA in 18/22 cases, and with 3D TOF MRA in 21/22 cases. There was no significant difference in patent aneurysm component size between CE-MRA and 3D TOF MRA. In addition, CE-MRA showed six, 3D TOF MRA before contrast injection showed seven, and 3D TOF MRA after contrast injection showed eight cases with patent aneurysm components not observed on DSA.

Conclusion: 3D TOF MRA was highly sensitive for detection of patent aneurysm components, and at least as sensitive as CE-MRA. Residual aneurysm patency seems to be better visualized with MRA than with DSA in some cases.

Publication types

  • Clinical Trial

MeSH terms

  • Angiography, Digital Subtraction / methods
  • Carotid Artery, Internal / diagnostic imaging
  • Contrast Media / administration & dosage
  • Embolization, Therapeutic / methods*
  • Follow-Up Studies
  • Gadolinium DTPA
  • Humans
  • Image Enhancement / methods
  • Image Processing, Computer-Assisted / methods
  • Imaging, Three-Dimensional / methods*
  • Intracranial Aneurysm / diagnosis*
  • Intracranial Aneurysm / therapy*
  • Magnetic Resonance Angiography / methods*
  • Platinum / therapeutic use*
  • Predictive Value of Tests
  • Prospective Studies
  • Reference Standards
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Treatment Outcome
  • Vascular Patency
  • Vertebral Artery / diagnostic imaging


  • Contrast Media
  • Platinum
  • gadodiamide
  • Gadolinium DTPA