The role of protective HCP5 and HLA-C associated polymorphisms in the control of HIV-1 replication in a subset of elite suppressors

AIDS. 2008 Feb 19;22(4):541-4. doi: 10.1097/QAD.0b013e3282f470e4.


Elite suppressors (ES) are untreated HIV-1-infected patients who maintain undetectable viral loads. A recent whole-genome analysis identified two independent polymorphisms associated with low viral loads in untreated HIV-1 infection. We screened 16 ES; none were positive for the protective HLA complex 5 gene polymorphism, and only four were positive for the protective polymorphism associated with the HLA-C gene. These results suggest that some ES control viremia by mechanisms independent of the newly-identified genetic factors.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Genotype
  • HIV Infections / genetics*
  • HIV-1 / genetics*
  • HIV-1 / physiology
  • HLA-C Antigens / genetics*
  • Heterozygote
  • Homozygote
  • Humans
  • Major Histocompatibility Complex / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • RNA, Long Noncoding
  • RNA, Untranslated
  • Viremia / genetics
  • Virus Replication / genetics*


  • HCP5 long noncoding RNA, human
  • HLA-C Antigens
  • RNA, Long Noncoding
  • RNA, Untranslated