Lymphoid tissue formation in allografts: innocent until proven guilty

Transplantation. 2008 Feb 15;85(3):309-11. doi: 10.1097/TP.0b013e318162d2d0.


Tertiary lymphoid organs (TLOs) are lymphoid-like structures commonly found at sites of chronic inflammation. Commonly associated with autoimmune responses, they have recently been described within organ allografts. Although TLOs are similar structurally to secondary lymphoid organs, their function remains largely unknown. In this review, we discuss how immune responses within TLOs may influence graft survival.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation / immunology
  • Graft Survival / immunology
  • Humans
  • Lymphoid Tissue / cytology*
  • Lymphoid Tissue / immunology*
  • Lymphoid Tissue / pathology
  • Transplantation, Homologous / immunology
  • Transplantation, Homologous / pathology