Evidence for prolonged prescribing of aspirin-clopidogrel combination in Scottish primary care

Pharmacoepidemiol Drug Saf. 2008 Apr;17(4):397-400. doi: 10.1002/pds.1561.

Abstract

Purpose: To identify whether patients were prescribed the combination of aspirin-clopidogrel in primary care after the generally recommended 12-month period.

Methods: A population based cross-sectional study using data from 61 general practices (1st April 2003-31st March 2004).

Results: 691 patients (0.18% of total population) were prescribed aspirin-clopidogrel in combination. 27.78% of these patients had undergone coronary stenting or angioplasty and 34.30% were prescribed this combination for more than 1 year. 96 (13.9%) patients had a previous history of ischaemic stroke or transient ischaemic attack.

Conclusions: Patients were prescribed the combination of aspirin-clopidogrel beyond the generally accepted 12-month period, which may lead to increased safety and cost concerns.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aspirin / adverse effects
  • Aspirin / therapeutic use*
  • Cardiovascular Diseases / drug therapy*
  • Cardiovascular Diseases / prevention & control
  • Clopidogrel
  • Cross-Sectional Studies
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Population Surveillance / methods
  • Primary Health Care / statistics & numerical data*
  • Retrospective Studies
  • Scotland
  • Ticlopidine / adverse effects
  • Ticlopidine / analogs & derivatives*
  • Ticlopidine / therapeutic use

Substances

  • Platelet Aggregation Inhibitors
  • Clopidogrel
  • Ticlopidine
  • Aspirin