Capnellenes from the Formosan soft coral Capnella imbricata

J Nat Prod. 2008 Apr;71(4):619-21. doi: 10.1021/np0706116. Epub 2008 Feb 27.

Abstract

Three anti-inflammatory sesquiterpenes, Delta (9(12))-capnellene-8beta,10alpha-diol ( 1), 8alpha-acetoxy-Delta (9(12))-capnellene-10alpha-ol ( 2), and Delta (9(12))-capnellene-10alpha-ol-8-one ( 3), five new sesquiterpenes, Delta (9(12))-capnellene-8beta,15-diol ( 4), Delta (9(12))-capnellene-8beta,10alpha,13-triol ( 5), Delta (9(10))-capnellene-12-ol-8-one ( 6), 8beta,10alpha-diacetoxy-Delta (9(12))-capnellene ( 7), and 8beta-acetoxy-Delta (9(12))-capnellene ( 8), and a known sesquiterpene, Delta (9(12))-capnellene-8beta-ol ( 9), were isolated from the acetone/methylene chloride extracts of the Formosan soft coral Capnella imbricata. The structures of these compounds were elucidated by extensive spectroscopic analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Lipopolysaccharides / pharmacology
  • Mice
  • Molecular Structure
  • Nitric Oxide Synthase Type II / metabolism
  • Nuclear Magnetic Resonance, Biomolecular
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Taiwan

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Lipopolysaccharides
  • Sesquiterpenes
  • Nitric Oxide Synthase Type II