Biomarkers of inflammation predict both vascular and non-vascular mortality in older men

Eur Heart J. 2008 Mar;29(6):800-9. doi: 10.1093/eurheartj/ehn049. Epub 2008 Feb 25.


Aims: To compare the predictive value of inflammatory biomarkers and lipids for vascular and non-vascular mortality in older men.

Methods and results: The relevance of inflammatory biomarkers and lipids for vascular and non-vascular mortality was assessed in a prospective study of 5360 men (mean age 77 years) followed for 7 years. Vascular mortality was positively associated with log C-reactive protein (lnCRP), fibrinogen and total/HDL-C (high-density lipoprotein cholesterol), and inversely associated with albumin [age adjusted hazard ratio (HR) per 2-SD higher usual level (approximately the difference between the top and the bottom thirds of the distribution): 2.09 for lnCRP; 1.70 for fibrinogen; 0.50 for albumin and 1.45 for total/HDL-C]. The associations with the inflammatory markers were attenuated after adjustment for established risk factors, including lipids [adjusted HRs: 1.86 (lnCRP); 1.44 (fibrinogen); 0.51 (albumin)], and further attenuated (and, for fibrinogen, no longer predictive) after adjustment for each other [fully adjusted HRs: 1.60 (lnCRP); 1.01 (fibrinogen); 0.61 (albumin)]. Higher CRP and lower albumin levels were also associated with significantly raised non-vascular mortality independently of other characteristics [fully adjusted HRs: 1.62 (lnCRP); 0.65 (albumin)].

Conclusion: In this cohort of older men, higher CRP and lower albumin levels strongly predicted both vascular and non-vascular mortality, independently of other characteristics.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biomarkers / metabolism*
  • C-Reactive Protein / metabolism
  • Cholesterol, HDL / metabolism
  • Cholesterol, LDL / metabolism
  • Fibrinogen / metabolism
  • Humans
  • London / epidemiology
  • Male
  • Myocardial Ischemia / metabolism
  • Myocardial Ischemia / mortality
  • Prospective Studies
  • Risk Factors
  • Serum Albumin / metabolism
  • Survival Rate
  • Vasculitis / blood
  • Vasculitis / mortality*


  • Biomarkers
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Serum Albumin
  • Fibrinogen
  • C-Reactive Protein