Quality of life in patients with chronic obstructive pulmonary disease: the predictive validity of the BODE index

Chron Respir Dis. 2008;5(1):7-11. doi: 10.1177/1479972307082329.


Background: Chronic obstructive pulmonary disease (COPD) is currently the fourth cause of mortality and morbility in the developed world. Patients with COPD experience a progressive deterioration of health-related quality of life (HRQOL). A new model of severity classification, the body mass index, bronchial obstruction, dyspnoea, exercise (BODE) index, has recently been proposed.

Objective: To evaluate the relationship between HRQOL and the BODE index, and the predictive ability of BODE on HRQOL measurements.

Methods: Two HRQOL questionnaires were administered, namely the Nottingham Health Profile (NHP) and St George's Respiratory Questionnaire (SGRQ), in a sample of 67 patients with severe COPD.

Results: Pearsonś correlation coefficient analysis shows a positive correlation between the BODE index and the total scores of the specific (P < 0.001), and general HRQOL (P < 0.001); the analysis shows a significant correlation between the BODE index and the subscales of symptoms, activity and impact of SGRQ (P < 0.001) and the subscales energy and physical mobility of the NHP (P < 0.001). The regression analysis shows that the BODE index is a significant predictor of HRQOL, explaining 46,1% of the total score of the SGRQ (P < 0.001) and 14.8% of the total score of the NHP (P < 0.001).

Conclusions: The BODE index is good at predicting the worsening of HRQOL in patients with severe COPD.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Exercise Test
  • Female
  • Health Status Indicators*
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Pulmonary Disease, Chronic Obstructive* / rehabilitation
  • Quality of Life*
  • Regression Analysis
  • Reproducibility of Results
  • Surveys and Questionnaires