P300-based BCI mouse with genetically-optimized analogue control

IEEE Trans Neural Syst Rehabil Eng. 2008 Feb;16(1):51-61. doi: 10.1109/TNSRE.2007.913184.


In this paper we propose a brain-computer interface (BCI) mouse based on P300 waves in electroencephalogram (EEG) signals. The system is analogue in that at no point a binary decision is made as to whether or not a P300 was actually produced in response to the stimuli. Instead, the 2-D motion of the pointer on the screen, using a novel BCI paradigm, is controlled by directly combining the amplitudes of the output produced by a filter in the presence of different stimuli. This filter and the features to be combined within it are optimised by an evolutionary algorithm.

MeSH terms

  • Adult
  • Algorithms
  • Brain / physiology*
  • Computer Graphics
  • Electrodes
  • Electroencephalography
  • Event-Related Potentials, P300 / genetics*
  • Event-Related Potentials, P300 / physiology*
  • Female
  • Humans
  • Male
  • Psychomotor Performance / physiology
  • User-Computer Interface*