How Saccharomyces responds to nutrients

Annu Rev Genet. 2008;42:27-81. doi: 10.1146/annurev.genet.41.110306.130206.

Abstract

Yeast cells sense the amount and quality of external nutrients through multiple interconnected signaling networks, which allow them to adjust their metabolism, transcriptional profile and developmental program to adapt readily and appropriately to changing nutritional states. We present our current understanding of the nutritional sensing networks yeast cells rely on for perceiving the nutritional landscape, with particular emphasis on those sensitive to carbon and nitrogen sources. We describe the means by which these networks inform the cell's decision among the different developmental programs available to them-growth, quiescence, filamentous development, or meiosis/sporulation. We conclude that the highly interconnected signaling networks provide the cell with a highly nuanced view of the environment and that the cell can interpret that information through a sophisticated calculus to achieve optimum responses to any nutritional condition.

Publication types

  • Review

MeSH terms

  • Amino Acids / metabolism
  • Cyclic AMP-Dependent Protein Kinases / metabolism
  • DNA-Binding Proteins
  • Genes, Fungal
  • Glucose / metabolism
  • Metabolic Networks and Pathways
  • Models, Biological
  • Nitrogen / metabolism
  • Protein-Serine-Threonine Kinases / metabolism
  • Repressor Proteins / metabolism
  • Saccharomyces / cytology
  • Saccharomyces / genetics
  • Saccharomyces / growth & development
  • Saccharomyces / metabolism*
  • Saccharomyces cerevisiae Proteins / metabolism
  • Signal Transduction
  • Stress, Physiological
  • Trans-Activators / metabolism
  • Transcription Factors
  • Transcription, Genetic
  • ras Proteins / metabolism

Substances

  • Amino Acids
  • DNA-Binding Proteins
  • RGT1 protein, S cerevisiae
  • Repressor Proteins
  • Saccharomyces cerevisiae Proteins
  • Trans-Activators
  • Transcription Factors
  • SNF1-related protein kinases
  • Protein-Serine-Threonine Kinases
  • target of rapamycin protein, S cerevisiae
  • Cyclic AMP-Dependent Protein Kinases
  • ras Proteins
  • Glucose
  • Nitrogen