Childhood bullous pemphigoid in association with hyperimmunoglobulin E syndrome

Pediatr Dermatol. 2008 Jan-Feb;25(1):28-33. doi: 10.1111/j.1525-1470.2007.00577.x.


Bullous pemphigoid is an acquired immunobullous disorder affecting predominantly the elderly. It is very rare in children and exceptional in infants. Hyperimmunoglobulin E syndrome is a rare primary immunodeficiency characterized by a triad of high serum levels of polyclonal immunoglobulin E with peripheral eosinophilia, recurrent staphylococcal infections of the skin and lungs, and pruritic dermatitis. Variable associated features include coarse facies, cold cutaneous abscesses, and osteopenia. This report describes, to the best of my knowledge, the first instance of childhood bullous pemphigoid associated with hyperimmunoglobulin E syndrome in a 6-month-old boy.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Administration, Oral
  • Adrenal Cortex Hormones / administration & dosage
  • Amoxicillin / administration & dosage
  • Drug Therapy, Combination
  • Follow-Up Studies
  • Humans
  • Infant
  • Infusions, Intravenous
  • Job Syndrome / complications
  • Job Syndrome / diagnosis*
  • Job Syndrome / drug therapy*
  • Male
  • Pemphigoid, Bullous / complications
  • Pemphigoid, Bullous / diagnosis*
  • Pemphigoid, Bullous / drug therapy*
  • Risk Assessment
  • Severity of Illness Index
  • Treatment Outcome


  • Adrenal Cortex Hormones
  • Amoxicillin