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Review
. 2008 Mar;15(3):193-9.
doi: 10.1111/j.1442-2042.2007.01956.x.

Alpha1-adrenoceptor subtypes and lower urinary tract symptoms

Debra A Schwinn  1 , Claus G Roehrborn
Affiliations
Review

Alpha1-adrenoceptor subtypes and lower urinary tract symptoms

Debra A Schwinn et al. Int J Urol. 2008 Mar.

Abstract

Benign prostatic hyperplasia (BPH) is a common cause of urinary outflow obstruction in aging men leading to lower urinary tract symptoms (LUTS). alpha(1)-Adrenoceptors (alpha(1)ARs) antagonists (blockers) have become a mainstay of LUTS treatment because they relax prostate smooth muscle and decrease urethral resistance, as well as relieving bladder LUTS symptoms. A review of key recent clinical trials suggests new insights into the role of specific alpha(1)AR subtypes in the treatment of LUTS.

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