Intron mis-splicing: no alternative?

Genome Biol. 2008;9(2):208. doi: 10.1186/gb-2008-9-2-208. Epub 2008 Feb 19.


A recent report reveals widespread mis-splicing of RNA transcripts in eukaryotes, with mis-spliced RNA destroyed by nonsense-mediated mRNA decay. This striking inefficiency deepens the mystery of the proliferation and persistence of introns.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alternative Splicing*
  • Animals
  • Genome*
  • Humans
  • Introns / genetics*
  • RNA Stability
  • Spliceosomes
  • Transcription, Genetic