Malignant advanced granulosa cell tumor of the adult testis: case report and review of the literature

Hum Pathol. 2008 May;39(5):701-9. doi: 10.1016/j.humpath.2007.09.015. Epub 2008 Mar 4.


Testicular granulosa cell tumors (GCTs) are very rare neoplasms. Although adult GCTs are thought to have a relatively indolent course, several reports have demonstrated the malignant potential of these lesions. In case of distant metastases, the overall survival is very short. To date, there is no well-established treatment for these tumors owing to poor results and very rapid progression. A 55-year-old male patient was diagnosed with a testicular GCT with distant lung metastases. He underwent surgical treatment with orchiectomy and adjuvant polychemotherapy (cisplantine, etoposide, and bleomycine) as well as metastasectomy of the right lung. We report the first case of a successfully treated testicular GCT with bipulmonary metastases at initial diagnosis. Thirty-nine months after treatment, the patient is alive with no evidence of disease. We subsequently reviewed all reported cases of an adult GCT in the published literature (25 published cases). This review will summarize all reported cases and discuss treatment options. The current case suggests that a combination of varying treatment modalities could be a promising and reasonable way to manage malignant advanced GCT of the adult testis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Combined Modality Therapy
  • Granulosa Cell Tumor / pathology*
  • Granulosa Cell Tumor / therapy
  • Humans
  • Lung Neoplasms / secondary
  • Lung Neoplasms / therapy
  • Male
  • Middle Aged
  • Testicular Neoplasms / pathology*
  • Testicular Neoplasms / therapy