LPS/TLR4 signal transduction pathway

Cytokine. 2008 May;42(2):145-151. doi: 10.1016/j.cyto.2008.01.006. Epub 2008 Mar 4.


The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years. Here we review molecules involved in TLR4-mediated signaling, including players that are involved in the negative regulation of this important pathway.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Lipopolysaccharides / pharmacology*
  • Signal Transduction / immunology*
  • Toll-Like Receptor 4 / physiology*


  • Lipopolysaccharides
  • TLR4 protein, human
  • Toll-Like Receptor 4