Treatment of akinetic mutism with intramuscular olanzapine: a case series

J Neuropsychiatry Clin Neurosci. 2008 Winter;20(1):93-5. doi: 10.1176/jnp.2008.20.1.93.


Akinetic mutism is a wakeful state of severe apathy and paucity of volitional movement. Evidence indicates a possible dopaminergic hypofunction within the anterior cingulate cortex. The authors present three cases of acute onset akinetic mutism successfully treated with intramuscular olanzapine.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Akinetic Mutism / drug therapy*
  • Antipsychotic Agents / administration & dosage*
  • Benzodiazepines / administration & dosage*
  • Female
  • Humans
  • Injections, Intramuscular / methods
  • Male
  • Middle Aged
  • Olanzapine


  • Antipsychotic Agents
  • Benzodiazepines
  • Olanzapine