Abstract
Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, was isolated from the culture broth of Streptomyces sp. K04-0144 by Diaion HP-20 and ODS column chromatographies and preparative HPLC. The structure of cyslabdan was elucidated by spectroscopic analyses including NMR. The compound has a labdane-type diterpene skeleton connecting with an N-acetylcysteine via thioether linkage.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcysteine / administration & dosage
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Acetylcysteine / analogs & derivatives*
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Acetylcysteine / chemistry
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Acetylcysteine / isolation & purification
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Acetylcysteine / metabolism
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / biosynthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Diterpenes / administration & dosage
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / metabolism
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Drug Synergism
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Fermentation
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Humans
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Imipenem / administration & dosage*
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Magnetic Resonance Spectroscopy
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Methicillin Resistance
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Microscopy, Electron, Scanning
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Molecular Conformation
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Molecular Structure
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / isolation & purification
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Streptomyces / classification
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Streptomyces / metabolism*
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Streptomyces / ultrastructure
Substances
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Anti-Bacterial Agents
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Diterpenes
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cyslabdan
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Imipenem
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Acetylcysteine