Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Streptomyces sp. K04-0144. I. Taxonomy, fermentation, isolation and structural elucidation

J Antibiot (Tokyo). 2008 Jan;61(1):1-6. doi: 10.1038/ja.2008.101.

Abstract

Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, was isolated from the culture broth of Streptomyces sp. K04-0144 by Diaion HP-20 and ODS column chromatographies and preparative HPLC. The structure of cyslabdan was elucidated by spectroscopic analyses including NMR. The compound has a labdane-type diterpene skeleton connecting with an N-acetylcysteine via thioether linkage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcysteine / administration & dosage
  • Acetylcysteine / analogs & derivatives*
  • Acetylcysteine / chemistry
  • Acetylcysteine / isolation & purification
  • Acetylcysteine / metabolism
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / biosynthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Diterpenes / administration & dosage
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / metabolism
  • Drug Synergism
  • Fermentation
  • Humans
  • Imipenem / administration & dosage*
  • Magnetic Resonance Spectroscopy
  • Methicillin Resistance
  • Microscopy, Electron, Scanning
  • Molecular Conformation
  • Molecular Structure
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / isolation & purification
  • Streptomyces / classification
  • Streptomyces / metabolism*
  • Streptomyces / ultrastructure

Substances

  • Anti-Bacterial Agents
  • Diterpenes
  • cyslabdan
  • Imipenem
  • Acetylcysteine