Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-alpha by inhibiting activation of NF-kappaB

Tae Wook Kyung; Ji Eun Lee; Hyun Hee Shin; Hye Seon Choi

doi:10.3858/emm.2008.40.1.52

Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-alpha by inhibiting activation of NF-kappaB

Exp Mol Med. 2008 Feb 29;40(1):52-8. doi: 10.3858/emm.2008.40.1.52.

Authors

Tae Wook Kyung¹, Ji Eun Lee, Hyun Hee Shin, Hye Seon Choi

Affiliation

¹ Department of Biological Sciences and Immunomodulation Research Center, University of Ulsan, Ulsan 680-749, Korea.

Abstract

Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-kappaB ligand (RANKL) in bone marrow-derived macrophages. It reduces reactive oxygen species produced by RANKL and its inhibitory effect results from reduced levels of TNF-alpha. Rutin also lowers NF-kappaB activation in response to RANKL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Mice
Mice, Inbred C57BL
NF-kappa B / metabolism*
Osteoclasts / cytology*
Osteoclasts / drug effects*
RANK Ligand / pharmacology
Reactive Oxygen Species / metabolism*
Rutin / pharmacology*
Tumor Necrosis Factor-alpha / metabolism*
Tumor Necrosis Factor-alpha / pharmacology

Substances

NF-kappa B
RANK Ligand
Reactive Oxygen Species
Tumor Necrosis Factor-alpha
Rutin