Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-alpha by inhibiting activation of NF-kappaB

Exp Mol Med. 2008 Feb 29;40(1):52-8. doi: 10.3858/emm.2008.40.1.52.


Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-kappaB ligand (RANKL) in bone marrow-derived macrophages. It reduces reactive oxygen species produced by RANKL and its inhibitory effect results from reduced levels of TNF-alpha. Rutin also lowers NF-kappaB activation in response to RANKL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Mice
  • Mice, Inbred C57BL
  • NF-kappa B / metabolism*
  • Osteoclasts / cytology*
  • Osteoclasts / drug effects*
  • RANK Ligand / pharmacology
  • Reactive Oxygen Species / metabolism*
  • Rutin / pharmacology*
  • Tumor Necrosis Factor-alpha / metabolism*
  • Tumor Necrosis Factor-alpha / pharmacology


  • NF-kappa B
  • RANK Ligand
  • Reactive Oxygen Species
  • Tumor Necrosis Factor-alpha
  • Rutin