Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum

J Invest Dermatol. 2008 Aug;128(8):2117-9. doi: 10.1038/jid.2008.29. Epub 2008 Feb 28.
No abstract available

Publication types

  • Letter

MeSH terms

  • Adult
  • Biomarkers / metabolism
  • Case-Control Studies
  • Dermatitis, Atopic / complications
  • Dermatitis, Atopic / metabolism
  • Epidermis / metabolism*
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Intermediate Filament Proteins / genetics*
  • Intermediate Filament Proteins / metabolism*
  • Male
  • Middle Aged
  • Mutation / genetics*
  • Water Loss, Insensible / genetics*

Substances

  • Biomarkers
  • Intermediate Filament Proteins
  • filaggrin