Lifelong consumption of sodium selenite: gender differences on blood-brain barrier permeability in convulsive, hypoglycemic rats

Biol Trace Elem Res. 2008 Jul;124(1):12-9. doi: 10.1007/s12011-008-8101-3. Epub 2008 Feb 28.


The aim of this study was to compare the effects of hypoglycemia and induced convulsions on the blood-brain barrier permeability in rats with or without lifelong administration of sodium selenite. There is a significant decrease of the blood-brain barrier permeability in three brain regions of convulsive, hypoglycemic male rats treated with sodium selenite when compared to sex-matched untreated rats (p<0.05), but the decrease was not significant in female rats (p>0.05). The blood-brain barrier permeability of the left and right hemispheres of untreated, moderately hypoglycemic convulsive rats of both genders was better than their untreated counterparts (p<0.05). Our results suggest that moderate hypoglycemia and lifelong treatment with sodium selenite have a protective effect against blood-brain barrier permeability during convulsions and that the effects of sodium selenite are gender-dependent.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Pressure
  • Blood-Brain Barrier / metabolism*
  • Female
  • Hypoglycemia / metabolism*
  • Male
  • Rats
  • Rats, Wistar
  • Seizures / metabolism*
  • Sex Characteristics*
  • Sodium Selenite / administration & dosage*
  • Sodium Selenite / metabolism
  • Sodium Selenite / pharmacology*
  • Time Factors


  • Sodium Selenite