Risk factors for gastrointestinal complications in aspirin users: review of clinical and experimental data

Dig Dis Sci. 2008 Oct;53(10):2604-15. doi: 10.1007/s10620-007-0178-6. Epub 2008 Feb 28.


This paper reviews recent clinical evidence that suggests that aspirin prophylaxis against cardiac and cerebral vascular ischemia is associated with significant gastrointestinal complications. The clinical and experimental evidence to confirm the role of risk factors of concomitant use of nonsteroidal anti-inflammatory drugs (NSAID), tobacco cigarette smoking, and alcohol consumption are discussed. The limitations of long-term acid suppression treatment for the prevention of these complications are considered. Future experimental studies to guide the clinical approach to develop novel and potentially cost-effective management strategies are discussed.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Alcohol Drinking / adverse effects
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Aspirin / adverse effects*
  • Humans
  • Risk Factors
  • Smoking / adverse effects
  • Stomach Ulcer / epidemiology*
  • Vascular Diseases / prevention & control


  • Anti-Inflammatory Agents, Non-Steroidal
  • Aspirin