Targeted Delivery of Nanoparticles for the Treatment of Lung Diseases

Adv Drug Deliv Rev. 2008 May 22;60(8):863-75. doi: 10.1016/j.addr.2007.11.006. Epub 2008 Feb 6.

Abstract

Targeted delivery of drug molecules to organs or special sites is one of the most challenging research areas in pharmaceutical sciences. By developing colloidal delivery systems such as liposomes, micelles and nanoparticles a new frontier was opened for improving drug delivery. Nanoparticles with their special characteristics such as small particle size, large surface area and the capability of changing their surface properties have numerous advantages compared with other delivery systems. Targeted nanoparticle delivery to the lungs is an emerging area of interest. This article reviews research performed over the last decades on the application of nanoparticles administered via different routes of administration for treatment or diagnostic purposes. Nanotoxicological aspects of pulmonary delivery are also discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal / administration & dosage
  • Drug Delivery Systems*
  • Gene Transfer Techniques
  • Humans
  • Lung / metabolism
  • Lung Diseases / drug therapy*
  • Magnetics
  • Nanoparticles / administration & dosage*
  • Nanoparticles / adverse effects

Substances

  • Antibodies, Monoclonal