Collapsing glomerulopathy: many means to a similar end

Kidney Int. 2008 Mar;73(6):669-71. doi: 10.1038/sj.ki.5002742.

Abstract

Collapsing glomerulopathy (CG) represents a morphologic pattern of disease, characterized histologically by glomerular capillary collapse, severe podocyte injury, and glomerular epithelial cell proliferation, and clinically by marked proteinuria and renal insufficiency. CG has multiple etiologies; however, many questions remain about its pathogenesis. A new set of animal models of CG, characterized by absence of the normal podocyte cytoskeletal protein alpha-actinin-4, has potential to help us gain a greater understanding of cellular events involved in producing this pattern of disease.

MeSH terms

  • Actinin / deficiency*
  • Actinin / genetics
  • Animals
  • Disease Models, Animal*
  • Glomerulonephritis / etiology*
  • Glomerulonephritis / genetics
  • Humans
  • Mice*
  • Mice, Knockout

Substances

  • Actn4 protein, mouse
  • Actinin