It's not all about nephrin

Kidney Int. 2008 Mar;73(6):671-3. doi: 10.1038/


Mutations in the NPHS1 gene cause congenital nephrotic syndrome of the Finnish type. The gene product nephrin is a structural component of the glomerular slit diaphragm formed by neighboring podocytes. Nephrin has also been suggested to be involved in signaling processes that are important for podocyte survival and differentiation. A new study by Doné et al. reports that the absence of nephrin leads to the lack of slit diaphragms but does not affect podocyte apoptosis and gene expression patterns.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis* / genetics
  • Disease Models, Animal
  • Gene Expression
  • Humans
  • Kidney Glomerulus / cytology
  • Kidney Glomerulus / metabolism*
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Mice
  • Mice, Knockout
  • Nephrotic Syndrome / genetics
  • Podocytes / metabolism*
  • Podocytes / ultrastructure*


  • Membrane Proteins
  • nephrin