Recurrent cytogenetic findings in subsets of patients with chronic lymphocytic leukemia expressing IgG-switched stereotyped immunoglobulins

Haematologica. 2008 Mar;93(3):473-4. doi: 10.3324/haematol.11872.


We report a remarkable association of recurrent (stereotyped) cytogenetic aberrations with two subsets of chronic lymphocytic leukemia (CLL) cases expressing IgG-switched, stereotyped B-cell receptors (BCRs). Comparison with cases with heterogeneous BCRs showed that these recurrent cytogenetic aberrations were subset-biased. These findings further support a role for antigen in CLL development.

MeSH terms

  • Chromosome Aberrations*
  • Complementarity Determining Regions / genetics*
  • Humans
  • Immunoglobulin G / genetics*
  • Immunoglobulin Switch Region
  • Leukemia, Lymphocytic, Chronic, B-Cell / classification
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • Leukemia, Lymphocytic, Chronic, B-Cell / immunology
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Neoplasm Proteins / genetics*
  • Receptors, Antigen, B-Cell / genetics*


  • Complementarity Determining Regions
  • Immunoglobulin G
  • Neoplasm Proteins
  • Receptors, Antigen, B-Cell