Negative correlation of anti-U1RNP antibody titers and the amount of salivary secretion with age correction

Intern Med. 2008;47(5):385-90. doi: 10.2169/internalmedicine.47.0426. Epub 2008 Mar 3.


Objective: The aim of this study was to reveal whether or not the presence of anti-U1RNP antibodies is associated with a low amount of salivary secretion (ASS).

Subjects and methods: Twenty females (mean age 49+/-12 years) who had anti-U1RNP but not ACA, anti-Ro, or anti-La antibodies (anti-U1RNP-positive group), and 65 control females (mean age 50+/-12 years) were included in this study. The saxon test was performed to measure the ASS.

Results: After a correction for age by ANCOVA, ASS in the anti-U1RNP-positive group was significantly lower than ASS in the control group (p <0.001). In the control group, ASS was not significantly decreased with advanced age (r=-0.140, p=0.211). In the anti-U1RNP-positive group, ASS was decreased with age, without a significant difference (r=-0.379, p=0.100). In the next analysis, we introduced 'ASS with age correction', assuming that all subjects in the anti-U1RNP-positive group were 49 years of age. A negative correlation between the titers of anti-U1RNP antibodies and the ASS with the age correction in the anti-U1RNP-positive group was noted (r=-0.520, p=0.019). The log of the antinuclear antibodies titers, or titers of rheumatoid factor was significantly correlated with the titers of anti-U1RNP antibodies, respectively (r=0.466, p=0.038 and r=0.595, p=0.006; respectively). The pathological findings of minor salivary gland biopsy in 2 subjects were compatible with Sjögren's syndrome; one subject showed moderate lymphocytic infiltration.

Conclusion: The presence of anti-U1RNP antibodies is associated with reduced ASS.

MeSH terms

  • Adult
  • Age Factors
  • Antibodies, Antinuclear / analysis*
  • Antibodies, Antinuclear / immunology
  • Autoantigens / immunology*
  • Case-Control Studies
  • Cohort Studies
  • Female
  • Humans
  • Middle Aged
  • Ribonucleoprotein, U1 Small Nuclear / immunology*
  • Saliva / chemistry
  • Saliva / immunology*
  • Salivary Glands / immunology
  • Salivary Glands / pathology
  • Salivation / immunology*
  • Sjogren's Syndrome / diagnosis
  • Sjogren's Syndrome / immunology*
  • snRNP Core Proteins


  • Antibodies, Antinuclear
  • Autoantigens
  • Ribonucleoprotein, U1 Small Nuclear
  • SNRNP70 protein, human
  • snRNP Core Proteins