The Cutaneous Lupus Erythematosus Disease Activity and Severity Index: expansion for rheumatology and dermatology

Arthritis Rheum. 2008 Mar 15;59(3):338-44. doi: 10.1002/art.23319.


Objective: To evaluate the validity of the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) for use by rheumatologists via reliability testing, and to extend the validation for dermatologists.

Methods: Fourteen subjects with cutaneous lupus erythematosus (CLE; n = 10), a mimicker skin disease only (a cutaneous lesion that may appear clinically similar to CLE; n = 1), or both (n = 3) were rated with the CLASI by academic-based dermatologists (n = 5) and rheumatologists (n = 5).

Results: The dermatology intraclass correlation coefficient (ICC) was 0.92 for activity and 0.82 for damage; for rheumatology the ICC was 0.83 for activity and 0.86 for damage. For intrarater reliability, the dermatology Spearman's rho was 0.94 for activity and 0.97 for damage; for rheumatology the Spearman's rho was 0.91 for activity and 0.99 for damage.

Conclusion: Our data confirm the reliability of the CLASI when used by dermatologists and support the CLASI as a reliable instrument for use by rheumatologists.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Adolescent
  • Adult
  • Dermatology*
  • Dermatomyositis / diagnosis*
  • Female
  • Humans
  • Lupus Erythematosus, Cutaneous / diagnosis*
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Rheumatology*
  • Sensitivity and Specificity
  • Severity of Illness Index*