Abstract
Total synthesis of salvinorin A (1), a neoclerodane diterpenoid having the most potent hallucinogenic activity and a selective kappa-opioid agonist, was completed in 20 steps starting from enantiomerically pure hydroxy-Wieland-Miescher ketone 5.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Diterpenes, Clerodane / chemical synthesis*
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Diterpenes, Clerodane / chemistry
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Hallucinogens / chemical synthesis*
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Hallucinogens / chemistry
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Molecular Structure
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Plants, Medicinal / chemistry
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Salvia / chemistry
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Stereoisomerism
Substances
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Diterpenes, Clerodane
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Hallucinogens
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salvinorin A