Enhanced muscle by myostatin propeptide increases adipose tissue adiponectin, PPAR-alpha, and PPAR-gamma expressions

Biochem Biophys Res Commun. 2008 May 2;369(2):767-73. doi: 10.1016/j.bbrc.2008.02.092. Epub 2008 Feb 27.


Muscle tissue utilizes a large portion of metabolic energy for its growth and maintenance. Previously, we demonstrated that transgenic over-expression of myostatin propeptide in mice fed a high-fat diet enhanced muscle mass and circulating adiponectin while the wild-type mice developed obesity and insulin resistance. To understand the effects of enhanced muscle growth on adipose tissue metabolism, we analyzed adiponectin, PPAR-alpha, and PPAR-gamma mRNA expressions in several fat tissues. Results indicated muscled transgenic mice fed a high-fat diet displayed increased epididymal adiponectin mRNA expression by 12 times over wild-type littermates. These transgenic mice fed either a high or normal fat diet also displayed significantly high levels of PPAR-alpha and PPAR-gamma expressions above their wild-type littermates in epididymal fat while their expressions in mesenteric fats were not significantly different between transgenic mice and their littermates. This study demonstrates that enhanced muscle growth has positive effects on fat metabolisms through increasing adiponectin expression and its regulations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / metabolism*
  • Animals
  • Dietary Fats / metabolism*
  • Gene Expression Regulation / physiology
  • Mice
  • Mice, Transgenic
  • Muscle, Skeletal / physiology*
  • Myostatin
  • PPAR alpha / metabolism*
  • PPAR gamma / metabolism*
  • Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta / metabolism*


  • Dietary Fats
  • Mstn protein, mouse
  • Myostatin
  • PPAR alpha
  • PPAR gamma
  • Transforming Growth Factor beta