Modular RNA Heats Up

Mol Cell. 2008 Feb 29;29(4):415-7. doi: 10.1016/j.molcel.2008.02.001.

Abstract

In this issue of Molecular Cell, Mariner et al. (2008) demonstrate that Alu RNA from a human SINE represses RNA polymerase II transcription during heat shock. This noncoding RNA is the first example of a "protein-like" transcription factor with a distinct modular architecture.

Publication types

  • Comment

MeSH terms

  • Animals
  • Heat-Shock Response / physiology
  • Humans
  • Nucleic Acid Conformation
  • RNA Polymerase II / antagonists & inhibitors
  • RNA Polymerase II / genetics
  • RNA Polymerase II / metabolism
  • RNA, Untranslated* / chemistry
  • RNA, Untranslated* / genetics
  • RNA, Untranslated* / metabolism
  • Short Interspersed Nucleotide Elements / genetics*
  • Transcription, Genetic*

Substances

  • RNA, Untranslated
  • RNA Polymerase II