A randomized, prospective trial of electrosurgical incision followed by rabeprazole versus bougie dilation followed by rabeprazole of symptomatic esophageal (Schatzki's) rings

Gastrointest Endosc. 2008 May;67(6):808-13. doi: 10.1016/j.gie.2007.10.062. Epub 2008 Mar 7.

Abstract

Background: Lower esophageal (Schatzki's) rings are a common cause of solid food dysphagia. Standard treatment involves passage of a single large bougie to disrupt the ring, but symptoms recur in the majority of patients. Electrosurgical incision of the ring may provide a longer duration of symptom improvement. There are no data on the treatment of Schatzki's rings in the presence of acid suppression treatment.

Objective: Our purpose was to compare the efficacy of bougie dilation with electrosurgical incision of symptomatic Schatzki's rings at 1-year follow-up in the presence of rabeprazole treatment.

Design: Randomized, prospective trial.

Setting: University of Utah Health Sciences Center and the Veterans Affairs Salt Lake.

Patients: Fifty patients referred for endoscopic evaluation of dysphagia between January 2002 and March 2005.

Main outcome measurements: Symptom-free survival time (in months), dysphagia, and GERD scores.

Results: Twenty-five patients each underwent bougie dilation and electrical incision and were followed up for 12 months. Symptom-free survival times were significantly longer in the incision group (7.99 months) compared with the bougie dilation group (5.86 months) (P = .03). Dysphagia and GERD scores significantly improved in each group comparing baseline with each time interval. The incision group had greater relief of dysphagia at 1 month (P = .05) compared with the bougie group. There was no difference between GERD scores in both groups.

Limitations: Dysphagia and GERD symptoms were self-reported.

Conclusions: Electrosurgical incision of Schatzki's rings is safe and offers longer symptom-free survival compared with bougie dilation. The addition of rabeprazole offered significant improvement in GERD scores in both groups.

Publication types

  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2-Pyridinylmethylsulfinylbenzimidazoles / therapeutic use*
  • Adult
  • Aged
  • Aged, 80 and over
  • Deglutition Disorders / etiology
  • Deglutition Disorders / pathology
  • Deglutition Disorders / therapy*
  • Dilatation / methods*
  • Electrosurgery / methods*
  • Enzyme Inhibitors / therapeutic use*
  • Esophageal Stenosis / complications
  • Esophageal Stenosis / pathology
  • Esophageal Stenosis / therapy*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Rabeprazole
  • Severity of Illness Index
  • Stereoisomerism
  • Time Factors
  • Treatment Outcome

Substances

  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Enzyme Inhibitors
  • Rabeprazole