Fatal colon cancer in a young egg donor: a physician mother's call for follow-up and research on the long-term risks of ovarian stimulation

Fertil Steril. 2008 Nov;90(5):2016.e1-5. doi: 10.1016/j.fertnstert.2007.12.074. Epub 2008 Mar 7.


Objective: To present a case report of fatal colon cancer in a young, previously healthy woman 4 years after repeated ovarian stimulation for egg donation, review previous publications on the risks of ovarian stimulation, and make recommendations for further egg donor follow-up, research, and actions by professional associations and regulatory agencies.

Design: Case report and review of the literature.

Setting: Case report and review of the literature.

Patient(s): One patient and published cases.

Intervention(s): None.

Main outcome measure(s): None.

Result(s): There has been no systematic study of the long-term risk of cancer or other adverse outcomes in healthy egg donors.

Conclusion(s): At present, potential egg donors cannot give truly informed consent because insufficient information exists about their long-term risks.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Biomedical Research
  • Colonic Neoplasms / etiology*
  • Fatal Outcome
  • Female
  • Government Regulation
  • Health Knowledge, Attitudes, Practice
  • Health Policy
  • Humans
  • Informed Consent
  • Mothers*
  • Oocyte Donation* / legislation & jurisprudence
  • Oocyte Retrieval* / legislation & jurisprudence
  • Ovulation Induction / adverse effects*
  • Patient Education as Topic
  • Physicians*
  • Risk Assessment
  • Risk Factors