In vivo confocal and multiphoton microendoscopy

J Biomed Opt. Jan-Feb 2008;13(1):010501. doi: 10.1117/1.2839043.


The ability to conduct high-resolution fluorescence imaging in internal organs of small animal models in situ and over time can make a significant impact in biomedical research. Toward this goal, we developed a real-time confocal and multiphoton endoscopic imaging system. Using 1-mm-diameter endoscopes based on gradient index lenses, we demonstrate video-rate multicolor multimodal imaging with cellular resolution in live mice.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Endoscopes*
  • Equipment Design
  • Equipment Failure Analysis
  • Microscopy, Confocal / instrumentation*
  • Microscopy, Fluorescence, Multiphoton / instrumentation*
  • Miniaturization
  • Reproducibility of Results
  • Sensitivity and Specificity