TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

Cell. 1991 Aug 23;66(4):649-61. doi: 10.1016/0092-8674(91)90111-b.


Previously we described joining of DNA in the beta T cell receptor gene to DNA of an uncharacterized locus in a t(7;9)(q34;q34.3) chromosomal translocation from a case of human T lymphoblastic leukemia (T-ALL). We now show that the locus on chromosome 9 contains a gene highly homologous to the Drosophila gene Notch. Transcripts of the human gene, for which we propose the name TAN-1, and its murine counterpart are present in many normal human fetal and adult mouse tissues, but are most abundant in lymphoid tissues. In t(7;9)(q34;q34.3) translocations from three cases of T-ALL, the breakpoints occur within 100 bp of an intron in TAN-1, resulting in truncation of TAN-1 transcripts. These observations suggest that TAN-1 may be important for normal lymphocyte function and that alteration of TAN-1 may play a role in the pathogenesis of some T cell neoplasms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Chromosome Aberrations / genetics
  • Chromosome Disorders
  • Chromosomes, Human, Pair 7
  • Chromosomes, Human, Pair 9
  • Cloning, Molecular
  • DNA / genetics
  • Gene Expression
  • Humans
  • Leukemia-Lymphoma, Adult T-Cell / genetics*
  • Membrane Proteins / genetics*
  • Mice
  • Molecular Sequence Data
  • Morphogenesis
  • Oligonucleotides / chemistry
  • Polymerase Chain Reaction
  • RNA, Messenger / genetics
  • Receptor, Notch1
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Antigen, T-Cell, alpha-beta
  • Receptors, Cell Surface*
  • Restriction Mapping
  • Transcription Factors*
  • Transcription, Genetic
  • Translocation, Genetic


  • Membrane Proteins
  • NOTCH1 protein, human
  • Notch1 protein, mouse
  • Oligonucleotides
  • RNA, Messenger
  • Receptor, Notch1
  • Receptors, Antigen, T-Cell
  • Receptors, Antigen, T-Cell, alpha-beta
  • Receptors, Cell Surface
  • Transcription Factors
  • DNA

Associated data

  • GENBANK/M73980