A case of fluoxetine-induced syndrome of inappropriate antidiuretic hormone secretion

Nat Clin Pract Nephrol. 2008 May;4(5):278-82. doi: 10.1038/ncpneph0780. Epub 2008 Mar 4.


Background: A 58-year-old schizophrenic male who had been drinking at least 4-5 l of pure water every day for 30 years was admitted to a hospital with complaints of nausea, fatigue, and irregular, fluctuating fevers (up to 39 degrees C). He had previously been prescribed fluoxetine at a dose of 20 mg/day and had been using the drug for 28 days.

Investigations: Review of medical history, physical examination, blood analysis, urine analysis, chest radiography and abdominal ultrasound.

Diagnosis: Psychogenic polydipsia and fluoxetine-induced syndrome of inappropriate antidiuretic hormone secretion.

Management: Fluid restriction and discontinuation of fluoxetine.

Publication types

  • Case Reports

MeSH terms

  • Fluoxetine / adverse effects*
  • Fluoxetine / therapeutic use
  • Follow-Up Studies
  • Humans
  • Inappropriate ADH Syndrome / chemically induced*
  • Inappropriate ADH Syndrome / physiopathology
  • Male
  • Middle Aged
  • Risk Assessment
  • Schizophrenia / diagnosis
  • Schizophrenia / drug therapy
  • Selective Serotonin Reuptake Inhibitors / adverse effects*
  • Selective Serotonin Reuptake Inhibitors / therapeutic use


  • Serotonin Uptake Inhibitors
  • Fluoxetine