Soluble triggering receptor expressed on myeloid cells 1 is released in patients with stable chronic obstructive pulmonary disease

Clin Dev Immunol. 2007;2007:52040. doi: 10.1155/2007/52040.

Abstract

Chronic obstructive pulmonary disease (COPD) is increasingly recognized as a systemic disease that is associated with increased serum levels of markers of systemic inflammation. The triggering receptor expressed on myeloid cells 1 (TREM-1) is a recently identified activating receptor on neutrophils, monocytes, and macrophage subsets. TREM-1 expression is upregulated by microbial products such as the toll-like receptor ligand lipoteichoic acid of Gram-positive or lipopolysaccharides of Gram-negative bacteria. In the present study, sera from 12 COPD patients (GOLD stages I-IV, FEV1 51 +/- 6%) and 10 healthy individuals were retrospectively analyzed for soluble TREM-1 (sTREM-1) using a newly developed ELISA. In healthy subjects, sTREM-1 levels were low (median 0.25 ng/mL, range 0-5.9 ng/mL). In contrast, levels of sTREM-1 in sera of COPD patients were significantly increased (median 11.68 ng/mL, range 6.2-41.9 ng/mL, P<.05). Furthermore, serum levels of sTREM-1 showed a significant negative correlation with lung function impairment. In summary, serum concentrations of sTREM-1 are increased in patients with COPD. Prospective studies are warranted to evaluate the relevance of sTREM-1 as a potential marker of the disease in patients with COPD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / blood*
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Membrane Glycoproteins / blood*
  • Membrane Glycoproteins / metabolism*
  • Pulmonary Disease, Chronic Obstructive / blood*
  • Pulmonary Disease, Chronic Obstructive / metabolism*
  • Pulmonary Disease, Chronic Obstructive / pathology
  • Receptors, Immunologic / blood*
  • Recombinant Proteins / blood
  • Recombinant Proteins / metabolism
  • Respiratory Function Tests
  • Retrospective Studies
  • Transfection
  • Triggering Receptor Expressed on Myeloid Cells-1

Substances

  • Biomarkers
  • Membrane Glycoproteins
  • Receptors, Immunologic
  • Recombinant Proteins
  • TREM1 protein, human
  • Triggering Receptor Expressed on Myeloid Cells-1