Roles of the hypocretin/orexins in the regulation of sleep and wakefulness

Jpn J Vet Res. 2008 Jan;55(2-3):75-83.

Abstract

Hypocretin/orexin is produced exclusively in the dorsal and lateral hypothalamus but its projection is widespread within the brain and plays important roles. In this paper, we review the independent discoveries of the hypocretin/orexin peptides, the neuroanatomy of this system, and the link to the sleep disorder narcolepsy that has led to the idea that this system plays a crucial role in the regulation of sleep and wakefulness.

Publication types

  • Review

MeSH terms

  • Animals
  • Homeostasis / physiology
  • Humans
  • Hypothalamus / metabolism*
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Intracellular Signaling Peptides and Proteins / physiology*
  • Narcolepsy / metabolism
  • Narcolepsy / veterinary*
  • Neuropeptides / physiology*
  • Orexins
  • Sleep / physiology*
  • Wakefulness / physiology*

Substances

  • Intracellular Signaling Peptides and Proteins
  • Neuropeptides
  • Orexins