Ixabepilone for the treatment of solid tumors: a review of clinical data

Expert Opin Investig Drugs. 2008 Mar;17(3):423-35. doi: 10.1517/13543784.17.3.423.

Abstract

Background: Microtubule stabilizing agents such as taxanes are an integral part of therapy for multiple solid tumors. However, due to limitations of these agents, newer more effective cytotoxic agents are necessary. Ixabepilone, an epothilone B analog, is a novel microtubule stabilizing agent.

Objective: This review provides an updated summary of emerging clinical experience with Ixabepilone.

Methods: Phase I, II and III clinical trials presented in abstract form or journal articles found within a PubMed search through November 2007 are described in this review.

Results/conclusion: Ixabepilone offers promising clinical activity in a variety of solid tumors. Ixabepilone is FDA-approved for the treatment of breast cancer refractory to anthracyclines and taxanes. The optimal dose and schedule are still being defined, and the predominant side effects are bone marrow suppression and neuropathy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / pharmacokinetics
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use*
  • Clinical Trials as Topic
  • Epothilones / adverse effects
  • Epothilones / pharmacokinetics
  • Epothilones / pharmacology
  • Epothilones / therapeutic use*
  • Humans
  • Neoplasms / drug therapy*
  • Treatment Outcome
  • Tubulin Modulators / adverse effects
  • Tubulin Modulators / pharmacokinetics
  • Tubulin Modulators / pharmacology
  • Tubulin Modulators / therapeutic use*

Substances

  • Antineoplastic Agents
  • Epothilones
  • Tubulin Modulators
  • ixabepilone