Premature ovarian failure and dehydroepiandrosterone

Fertil Steril. 2009 Feb;91(2):644-6. doi: 10.1016/j.fertnstert.2007.11.055. Epub 2008 Mar 5.


Since the first successful birth at our center following treatment with DHEA in a patient with premature ovarian failure (POF), all subsequent patients with POF underwent the same treatment protocol. Receiving very encouraging results (FSH level was decreased in the first five patients and all achieved pregnancy), it was decided to study the action of DHEA for a reasonable length of time and in a larger number of patients to confirm the effectiveness of this particular therapeutic regime.

MeSH terms

  • Adult
  • Dehydroepiandrosterone / therapeutic use*
  • Estradiol / blood
  • Female
  • Fertility Agents, Female / therapeutic use*
  • Follicle Stimulating Hormone, Human / blood
  • Humans
  • Infertility, Female / blood
  • Infertility, Female / drug therapy*
  • Infertility, Female / etiology
  • Luteinizing Hormone / blood
  • Pilot Projects
  • Pregnancy
  • Pregnancy Rate
  • Primary Ovarian Insufficiency / blood
  • Primary Ovarian Insufficiency / complications
  • Primary Ovarian Insufficiency / drug therapy*
  • Treatment Outcome


  • Fertility Agents, Female
  • Follicle Stimulating Hormone, Human
  • Dehydroepiandrosterone
  • Estradiol
  • Luteinizing Hormone