Complete response of CNS-involved olfactory neuroendocrine tumor using multimodal therapy

Onkologie. 2008 Mar;31(3):119-21. doi: 10.1159/000113505. Epub 2008 Feb 8.


Introduction: Locally advanced tumors in the olfactory area commonly have central nervous system (CNS) involvement and are often incurable.

Case report: We report the treatment of a 25-year-old male patient who presented with a large, neuroendocrine tumor arising from the ethmoid complex. This locally invasive lesion extended beyond the orbits and into the anterior cranial fossa with associated intracranial involvement. An endoscopic nasal biopsy demonstrated a poorly differentiated neuroendocrine tumor. The patient was treated with 4 cycles of combination induction chemotherapy with irinotecan and cisplatin followed by radiation therapy with concurrent weekly cisplatin. He had a complete response to this therapy confirmed with biopsies that demonstrated no residual disease at 8 weeks after chemoradiotherapy. He remained disease free one and a half years following surgery.

Conclusion: To our knowledge, this combination treatment approach has not been reported in the literature.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
  • Brain Neoplasms / therapy*
  • Camptothecin / analogs & derivatives
  • Cisplatin / administration & dosage
  • Ethmoid Bone / pathology*
  • Humans
  • Irinotecan
  • Male
  • Neuroendocrine Tumors / therapy*
  • Organization and Administration
  • Radiotherapy, Adjuvant*
  • Skull Neoplasms / therapy*


  • Irinotecan
  • Cisplatin
  • Camptothecin