TH2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity

Immunol Today. 1991 Jul;12(7):223-7. doi: 10.1016/0167-5699(91)90034-Q.


Systemic autoimmune diseases can be induced experimentally in rodents by graft-versus-host or host-versus-graft reactions and by chemicals such as HgCl2, gold salts and D-penicillamine. These models share several features, such as productions of anti-nuclear antibodies, immune glomerulonephritis, MHC class II hyperexpression on B cells, hyper-IgE, increased IL-4 activity and impairment of IL-2 production. This profile of cytokines suggests a central role for TH2-type cells in their pathogenesis. Here, Michel Goldman and colleagues review the data supporting this hypothesis and discuss the possible molecular bases for T-cell activation in chemically-induced systemic autoimmunity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / etiology
  • Autoimmunity*
  • Graft vs Host Disease / etiology
  • Host vs Graft Reaction
  • Lymphocyte Activation
  • T-Lymphocytes, Helper-Inducer / immunology*